Indigenous students in the United States experience disproportionate outcomes in school, including high rates of special education identification, suspension, and chronic absenteeism. Despite the systemic inequities that affect Native students, state educational agencies (SEAs) employ few staff who specialize in the education needs of these students. Each state has a single American Indian Education (AIE) Director, and, according to Region 15 Comprehensive Center (R15CC) project documents, a total of 11.5 full-time equivalent positions are assigned to supporting American Indian educational programs or services in Arizona, California, Nevada, and Utah. These SEA personnel serve a critical role in ensuring that the region's roughly 445,000 Native students and families affiliated with more than 166 federally recognized tribal governments located in these states have access to high-quality, equitable educational opportunities and outcomes. This brief describes the Community of Practice (CoP), designed and facilitated by the Region 15 Comprehensive Center, for American Indian Education Directors to meet and address systemic educational inequities and improve education for Indigenous students.