Skill mismatch, the discrepancy between the skill levels held by employees and those demanded by employers, has long been of interest to analysts of the labor market. Such mismatches are worth exploring to better understand the processes of recruitment and career development and the role of education in the labor market. This study aims to analyze a specific feature of skill mismatch -- gender differences in the prevalence of skill mismatch for each phase of the family life course. It also explores if a spouse's working status relates to the likelihood of being skill mismatched during a specific phase of the family life course. To this end, data were used from the Programme for the International Assessment of Adult Competencies (PIAAC). These data provide an opportunity to take crucial first steps in unraveling how skill mismatch varies by gender in each phase of the family life course. Findings provide significant implications for both research and policy on labor markets, as clarifying the determinants of skill mismatch might suggest means to better align the demands of the labor market with the home.