With research as a guide, designing CTE programs that promote equity and help close the opportunity gap is achievable. This is the fifth in a series of six practitioner training modules developed as part of the Career & Technical Education (CTE) Research Network Lead. Designed for CTE practitioners and state agency staff, these modules are designed to strengthen the capacity to access, understand, and use CTE data and research as well as conduct one's own research, particularly causal research. This module examines the student groups identified in the federal Strengthening Career and Technical Education for the 21st Century Act, better known as Perkins V, explains how to use data to ensure these students are served, and presents lessons learned and best practices for promoting equity in CTE and closing the opportunity gap. The module is designed to support school district and college CTE program administrators in using research to develop equitable CTE programs.