While changing demographics reflect an increasingly multicultural and multilingual U.S. population, Latinos continue to experience under-representation and lack of recognition inconsistent for such a growing segment of the U.S. population. Latinos face a myriad of inequities across systems that impact early childhood development and that continue to undermine the potential and future success of Latino infants, toddlers, and their families. This is characterized by educational, health, economic security, and immigration barriers as well as by other disparities. Addressing the specific needs of expecting Latino families and those who have young children under the age of three is crucial to build a prosperous future for the United States. This policy agenda was developed within the framework of the Latino Infant Initiative (LII), a collaboration between two leading organizations that serve the Latino community, UnidosUS and Abriendo Puertas/Opening Doors. The agenda provides a comprehensive policy framework that addresses the diverse needs of Latino infants and toddlers, from prenatal to age three, and their families. Recognizing the critical importance of the prenatal to three-year period, this agenda acknowledges the profound impact of early experiences on a child's development. Through an approach that considers the interconnectedness of issues that families experience, values research evidence, and embraces a child-centered and family-focused perspective, this agenda can serve as a roadmap for policymakers. [This document was developed with Abriendo Puertas/Opening Doors.]