The current U.S. secondary education, postsecondary education, and workforce training systems are failing to serve the needs of many of today's students. Securing a good job with a family-sustaining wage increasingly requires workers to possess industry certifications, degrees, and credentials, but U.S. education systems are not set up to help enough students secure them. In addition, there are significant economic disruptions on the horizon that are going to have big implications for the future of education and work. Jobs for the Future's Big Blur vision calls for entirely new educational institutions and systems to better prepare 16-to-20-year-olds for college and careers. This paper examines new structures for teaching and learning to help states create more effective grade 11-14 schools and systems, with examples of promising state-level instructor models. This paper outlines new types of instructor preparation, accountability systems, and learning management structures that are needed to effectively serve the developmental needs of young people in grades 11-14 and the unified system envisioned in the Big Blur.