The purpose of this quantitative, predictive correlational study was to investigate the relationship between leader self-efficacy, emotional intelligence, years of experience, and transformational leadership practices of physician assistant (PA) program directors. This study is important in providing a greater understanding of the internal determinants and factors that influence the program directors' beliefs in their success and effectiveness as leaders. Participants for this study included a sample of 86 PA program directors across the United States. Data were collected using the Leader Efficacy Questionnaire, Wong and Law Emotional Intelligence Scale, Leadership Practices Inventory, and a demographic questionnaire administered via a survey. Multiple linear regression was used to examine the predictive relationship between the variables. The findings revealed that there was a statistically significant predictive relationship between transformational leadership practices and the linear combination of leader self-efficacy, emotional intelligence, and years of experience (F(3, 82) = 15.40, p < 0.001, R[superscript 2] = 0.36). This study's findings can be used to develop more targeted professional development to enhance PA program directors' leadership effectiveness. Recommendations for future research include conducting qualitative research to gain a deeper understanding of program directors' use of transformational leadership, examining other demographic variables as predictors, and replicating the study in other health professions programs. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]