This paper illustrates the integration of the hybrid Problem-Based Learning (PBL) approach in the development of the prototype C[superscript 2]HADAM, a multimedia courseware that is intended for the teaching and learning of the Science subject for form two students in Malaysian secondary schools. The discussion begins with the Constructivist theory and conceptual frameworks underlying C[superscript 2]HADAM. The learning concepts of inquiry learning, contextual education, simulation, exploratory learning, self-directed learning, and student-centered learning are also incorporated into C[superscript 2]HADAM. Next, this paper details the development of the project using a popular development life cycle namely ADDIE. ADDIE life cycle consists of the analysis, design, development, implementation, and evaluation phases. This paper also highlights some of the screen snapshots taken from C[superscript 2]HADAM prototype. The final part of this paper presents some of the findings from the Effectiveness construct. The results show positive feedback on the use of the courseware, and the courseware proves to enhance learners' performance. The integration of the PBL principles in the development of the courseware, thus, promises more of its application in the teaching and learning of other scientific disciplines. [For the complete proceedings, see ED655360.]