The implementations and ongoing use of mobile information systems could enhance nursing workflows at the point of care. However, when a system is not perceived as easy to use or useful, the frequency of its use is decreased. This non-experimental quantitative study conducted a survey of inpatient bedside nurses and nurse leaders to determine how their perceptions and attitudes affected the use of mobile technology. Statistically significant positive correlations were found when the participants were asked if the mobile system gave them greater control over their work. A statistically significant relationship was found between bedside nurses and nurse leaders, where the leaders found the mobile system more useful than bedside nurses. The findings from this study suggest that a mobile system must be perceived as useful by nurses to have the highest frequency of usage. Nurses believed the mobile system supported critical aspects of their work, giving them greater control over their work. Conversely, nurse leaders believed the mobile technology was beneficial because it allowed them to accomplish more work than would otherwise be possible. The results of this study demonstrated the importance of understanding the perceptions of end-users regarding an information system. Further research is needed to generalize these findings and explore a broader scope of attitude and mobile documentation in healthcare. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]