The National Center on Accessible Educational Materials for Learning (National AEM Center) at CAST is a technical assistance (TA) center funded by the U.S. Department of Education, Office of Special Education Programs (OSEP). The purpose of the Center is to improve educational and employment opportunities for individuals with disabilities through TA activities that increase both the availability and the use of accessible materials and technology. The Center's stakeholders serve and advocate for individuals with disabilities and their families across the continuum of educational settings: early learning, K-12, and postsecondary academic and career training programs. The AEM Center's TA is guided by the Quality Indicators for the Provision of AEM and Accessible Technologies. The seven Quality Indicators describe the essential elements of a system that ensures the consistent, reliable, and timely provision of high-quality accessible materials and technology for all learners who need them, including those with disabilities. While intended to be implemented by a coordinated team of representatives from within a system (i.e., state, district, higher ed institution, or workforce agency), each individual representative needs an operational understanding of the Quality Indicators. It is through a collective understanding of individual roles and responsibilities that systems change occurs. The purpose of this guide is to facilitate both individual and collective understanding of the AEM Quality Indicators.