Increasing the number of Black men and Black women who enter the fields of science, engineering, and medicine (SEM) will benefit the social and economic health of the nation. On May 2-3, 2022 the Roundtable on Black Men and Black Women in Science, Engineering, and Medicine of the National Academies of Sciences, Engineering, and Medicine convened a workshop to highlight promising financial and supportive services and programs throughout various stages of career development. Sessions followed student progression through the major stages of education and career development, and identified policies and practices that aim to mitigate and alleviate long-standing barriers to the full participation of Black students in SEM at the K-12, undergraduate, and graduate and professional levels. [Lynne M. Holden and Louis W. Sullivan served as Rapporteurs. Contributors Policy and Global Affairs; Health and Medicine Division; and Roundtable on Black Men and Black Women in Science, Engineering, and Medicine.]