According to research, at least 50% of students participate in online courses as opposed to face-to-face courses in non-profit, Higher Education (HE) institutions. Relatively little research has explored the way students' performance in non-profit institutions is influenced by participating in an online course versus face-to-face course. As a result of research completed on this topic, it is evident more in-depth information is needed regarding evidence to understand the impact of online learning versus face-to-face learning today and their effect on students' performance. The purpose of this quantitative study was to compare the way students' performance in non-profit institutions is influenced by participating in an online course versus face-to-face course. The Online and Face-to-face Education Evaluation Tool (OFFEET), developed by this researcher, was chosen as the measurement instrument for this study. Participants of this study were university students at non-profit universities/colleges, for this study, there were 314 participants. One-way multivariate ANOVAs were computed with scores on the researcher-developed instrument, OFFEET and the independent variables (i.e., two covariates (gender and age), household income, type of device used, and region within the United States. The results of this research determined that there is a statistically significant difference in the relationship between online versus face-to-face student performance in nonprofit universities. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]