The purpose of this study was to evaluate the employee satisfaction rate and factors and influences on satisfaction among employees who work in IT Departments of healthcare organizations in the United States. Specifically, I explored the relationship between the organizational influences (organizational trust, sense of belonging, compensation, and training), motivation influences (attribution and expectancy), knowledge influences (expectations from leadership and procedural knowledge), and their relationship to employee satisfaction. Four research questions guided this study: (1.) What is the employee satisfaction rate in IT Departments within healthcare organizations? (2.) What is the relationship between organizational context and culture and employee satisfaction in IT Departments within healthcare organizations? (3.) What is the relationship between employee motivation and employee satisfaction in IT Departments within healthcare organizations? (4.) What is the relationship between employee knowledge and employee satisfaction in IT Departments within healthcare organizations? Using a quantitative research design, online surveys were shared via social media through LinkedIn, Twitter, Facebook, and via email, seeking information technology (IT) employees working in a healthcare setting. The population size was 56 respondents. Multiple regression analysis with p-value and Pearson's-r was used to explore the correlation between the dependent and independent variables. Results of the analysis found a positive correlation between employee satisfaction and the independent variables of trust, belonging, compensation, training, attribution motivation, expectancy motivation, and procedural knowledge. A positive correlation was found for compensation, training, and attribution. However, the mean of responses was below 75% for these variables, indicating a need to be developed to improve employee satisfaction. Recommendations were discussed for addressing these three variables. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]