Student motivation and engagement are essential to the teaching and learning process. This is especially true in quality Career and Technical Education (CTE) programs where students choose to enroll in classes in which they explore future career opportunities. The purpose of this research was to examine teachers' and students' perceptions of instructional approaches used to actively engage and motivate students enrolled in CTE Business, Engineering, and Health Science programs to determine which instructional strategies and approaches are perceived as highly effective. The study examined teachers' and students' responses to open-ended questions on the Student Engagement and Motivation Survey. A random selection process was used to identify the participants in this study: two to three students and their teachers from each CTE Business, Engineering, and Health Science class from two high schools in middle Tennessee. A total of 11 participants (five students and six teachers) completed the survey. This study had four research questions. Research findings suggested that CTE Business, Engineering, and Health Science teachers should seek students' interest, make learning relevant, and provide real-world experiences to actively engage and motivate students. Survey results revealed that hands-on activities, project-based learning, experiential learning, student grades, building relationships, and intrinsic and extrinsic motivators were strategies to actively engage and motivate students. Additional research is recommended to determine what instructional approaches are effective according to students' achievement data. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]