Student affairs professionals play an integral role in supporting college students' mental health and well-being. Yet the current literature lacks research that specifically documents these phenomena within this set of professionals. The COVID-19 pandemic created additional mental health and well-being concerns that are worth empirically exploring. The current study aims to document how student affairs professionals experience mental health and well-being in relation to their identity, functional area, salary, years of experience, and the COVID-19 pandemic, utilizing a mixed method, explanatory sequential design. Of the 327 American student affairs professionals that completed the demographic questions, 245 completed all items in this survey. Factors that impact mental health and well-being in this population (autonomy, competence, and relatedness) are also explored as outlined by the self-determination model of health behavior change. Data was analyzed using analysis of variance (ANOVA) and inductive thematic coding. Findings suggest that mental health in student affairs professionals is impacted by the following: a) workplace autonomy, b) competence-building, c) positive relationships, d) gender, e) salary, f) years of experience, and g) functional area. Psychological well-being is impacted by the following: a) workplace autonomy, b) positive relationships, c) salary, and d) functional area. How student affairs professionals' experienced COVID-19 was a function of race and ethnicity, work from home status, and functional area. Additional potential factors, as well as implications for this study are discussed. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]