College students are asked to make critical decisions about which academic major to choose and subsequently to make specific career decisions. Students come to college with a myriad of different skill sets, backgrounds, developmental levels, cognitive processes, familial support, and levels of self-efficacy that may influence how they make these decisions. The purpose of this study was to explore the role that epistemic cognition and self-efficacy may play in the career decision-making processes of college students utilizing a mixed methods approach. Results of this study indicate that there are internal and external influences that impact college students' career decision-making processes that should be viewed individually from within a student's unique ecosystem. Findings support the existence of career decision-making epistemic cognition which may provide higher education professionals with a new way to provide career decision-making assistance to their students. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]