Underrepresented minority students faced challenges while attending predominately White institutions which influenced their persistence. With the increase of diversity across colleges, there was a need for campus leaders to implement culturally responsive practices to address minority student retention and persistence. The purpose of my qualitative case study was to examine underrepresented minority students' perceptions of culturally responsive holistic support systems and its influence on persistence at a predominately White institution in the Southeast United States. For this study, I emailed questionnaires to underrepresented minority students who identified as Black, Hispanic, American Indian, and Multi-racial. I conducted two 20-minute observations of the campus environment to gain an understanding of minority student engagement, the cultural context in which study participants lived, and the relationships among and between groups. After reading and synthesizing 21 responses from study participants during the Spring 2023 academic year, eight themes emerged regarding underrepresented minority students' perceptions of their campus environment and campus support systems. I found for underrepresented minority students to navigate their campus environment, there was a need to create opportunities for meaningful and authentic relationships which influenced their persistence. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]