Despite growing evidence about the significance of Early Childhood Development (ECD) programs, public investment has been relatively low, resulting in slower expansion of evidence-based ECD programs. This dissertation consists of three essays on conducting and using economic evaluation methods to scale up early childhood education and development programs. Specifically, I conduct a benefit-cost analysis of the Chicago Child-Parent Center (CPC) preschool program, with a focus on health outcomes in mid-adulthood. Further, I analyze the costs of implementing the expansion of the CPC program to four districts in the Midwestern US. I discuss the costs required to scale up an evidence-based high-quality preschool program with a focus on estimating the marginal costs of each of the program's six quality elements. Finally, I review the existing economic evaluations of Nurse-Family Partnership Home Visiting programs and suggest two innovative financial mechanisms -- Pay for Success (PFS) and Data-Driven Philanthropy that can be used to expand access to home-visiting programs by leveraging public-private partnerships. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]