Student enrollment in online courses continues to grow as student retention rates continue to decrease. Student disengagement in learning directly impacts online nursing programs' attrition and retention rates. The problem addressed in this study was students' disengagement with learning in asynchronous online nursing courses. The bioecological student engagement framework, a framework for student engagement, and community of inquiry framework (CoI) were conceptual models guiding the research. The purpose of this quantitative correlational study was to examine relationship between comfort, community, facilitation, interaction and collaboration, and students' learning engagement in asynchronous online nursing courses. The target population consisted of 152 nursing students enrolled in online nursing courses within the United States. Research Question 1, 2, 3, and 4 involved the test of whether there was a positive, significant relationship between comfort, community, facilitation, interaction and collaboration and learning engagement in asynchronous online courses. The data collection method consisted of The Online Student Connectedness Survey. The data analysis results prompted rejection of all four null hypotheses associated with the problem of nursing students' disengagement with learning in asynchronous online nursing courses. The findings of this study implied that positive relationships were justified between comfort and learning engagement, community and learning engagement, facilitation and learning engagement, and interaction and collaboration and learning engagement, all within an asynchronous online course. Recommendations for future research are suggested between learning engagement and the following: a) external factors, b) demographics, c) differences in learning outcomes for traditional, asynchronous, and synchronous online settings. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]