Pathways to economic opportunity are broken in the United States, disproportionately affecting Black, Latinx, and Indigenous individuals and those from low-income backgrounds. Disrupting long-standing occupational segregation and improving outcomes for all will require a system of career navigation that gives all individuals economic agency and opportunity. Unlocking Economic Prosperity: Career Navigation in a Time of Rapid Change dissects the evidence and practice of career navigation and sets an agenda for a more equitable career navigation ecosystem. Based on an extensive literature review and consultation with experts and frontline workers, we identify the drivers of career navigation success and lay out core design principles and recommendations for the future. At a time of rapid technological transformation, policymakers, employers, educators, intermediaries, and philanthropies must collaborate to build a system of supports and pathways that provide all individuals with the information, skills, social capital, resources, and social structures they need to advance. [This paper was produced by the Harvard Kennedy School's Malcolm Wiener Center for Social Policy, the Harvard Business School Managing the Future of Work Project, and the Harvard Graduate School of Education as part of the Project on Workforce at Harvard.]