The expert knowledge of seven executive-level leaders in higher education in their response to COVID-19, an extreme environmental perpetration, was documented in this qualitative case study. The research problem explored the effectiveness of response by the presidents of institutions located in the Southeast Region of the United States, going in-depth about the traits, strategies, tactics, prior leadership development experience, and stakeholder consideration necessary for institutional survival and success. The theoretical framework of this qualitative case study was based on New Institutionalism Theory. Data collection included semi-structured interviews, anecdotal notes and observations, and a review of electronic documents (affiliated institutions' website information related to COVID-19). Semi-structured interviews were conducted until data saturation was reached. Interview responses were transcribed using Zoom technology. Data analysis took place through descriptive coding with the assistance of MAXQDA software. The researcher assigned four categories based on each research question. The coding process allowed the researcher to generate frequency charts with MAXQDA. In each category, significant themes were identified. During a crisis, best leadership practices revealed transparency as the most crucial trait. Following guidelines enforced by the federal government to keep everyone safe were the strategies and tactics which emerged. Prior leadership development included having years of experience with other crises. Considering, planning, and protecting the student stakeholder population appeared most prevalent. This research's findings and knowledge contribute to the field by adding a narrower focus on the impact of unexpected and immense environmental perpetrations on higher education organizations. The study offers a framework for higher education leaders to respond, ensuring organizational survival and success. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]