"The Appalachian Region: A Data Overview from the 2017-2021 American Community Survey," also known as "The Chartbook," draws from the most recent American Community Survey and comparable Census Population Estimates. The report contains over 300,000 data points about Appalachia's economy, income, employment, education, and other important indicators--all presented at regional, subregional, state, and county levels. Though that data was collected before, and during the initial ten months of, the COVID-19 pandemic, they provide a critical benchmark for comparison when more pandemic and post-pandemic information becomes available. [For the 2016-2020 Chartbook, see ED625962.]