Pressing social problems and inequities call attention to the need for interventions that target root causes and change systems. A significant challenge facing system change efforts is the lack of systems-based evaluation theory and methods. To address this challenge, we conducted an instrumental case study of evaluation within an exemplary philanthropy engaged in system change work for over a decade. Research questions address how the foundation envisions, supports, and evaluates system change. Data collection included document review and group and individual interviews with staff members followed by iterative two cycles of descriptive coding and analysis. We present fifteen findings followed by implications for practice of and research on system change evaluation.