The number of HSIs has increased to 571 in 2021-22 up from 559 in 2020-21 (the year HSIs decreased for the first time in decades due in part to enrollment declines, institutional closings, and consolidation during the pandemic). These 571 HSIs are located in 28 states, the District of Columbia, and Puerto Rico. As the number of HSIs is increasing, the number of eHSIs and gHSIs also continues to increase. In this fact sheet, we provide a summary of HSIs, Emerging HSIs (eHSIs), and HSIs with Graduate Programs (gHSIs). [For the 2020-2021 fact sheet, see ED623037.]