With more than 290 Career and Technical Education (CTE) programs across 131 high schools, the NYC Department of Education (NYCDOE) oversees one of the largest and most diverse CTE systems in the country. In the last year, NYC's mayor and NYCDOE leadership have made a number of new investments in Career and Technical Education. The Research Alliance for New York City Schools, in collaboration with researchers from MDRC, Boston College, and the University of Connecticut, has undertaken a multi-year study that looks to New York City as a laboratory for learning about the implementation, impact, and cost of the wide array of educational options that fall under the heading of Career and Technical Education. Evidence from this ongoing study is informing the work of the Office of Student Pathways, which includes the team that centrally manages CTE in particular. Given the wide-ranging conditions under which CTE is implemented in NYC, and the diversity of students it serves, the study has the potential to inform policy and programming decisions across the country. This report is the first of several that will emerge from the larger study. It assesses the impact of the CTE-Dedicated high schools on key student outcomes, including academic engagement in 9th through 12th grade, high school graduation, and college enrollment. It also examines the degree to which key program elements were available to students in CTE-Dedicated high schools, highlighting policies and programming decisions that shaped the orientation and impact of these programs during the study period. [This report was written with John Sludden and Samuel J. Kamin.]