Across the U.S. economy, large-scale changes in work are occurring because of skills disruption: the constant re-invention of work driven by the vigorous, accelerating demand for new skills in virtually all jobs, and the spread of those skills across industries and around the world. In the past half decade, the average U.S. worker has had to replace or upgrade over a third (37%) of their skills simply to keep up with the demands of their occupation. In order to better understand what is underway when emerging skills change jobs, workplaces, and even industries, and in order to inform leaders about how they can most effectively engage and respond to this new phenomenon, researchers conducted a landscape analysis to identify and then delve into areas of great transformation. This paper features an examination of four clusters of skills that are experiencing rapid rates of growth, are in high demand, and are spreading across industries and geographic regions. These four of the fastest-growing, highest-demand emerging skill sets are: (1) Artificial Intelligence/Machine Learning; (2) Cloud Computing; (3) Product Management; and (4) Social Media. [Additional partners of this report include the Burning Glass Institute and Wiley.]