This report puts forward practical actions to address economic and social disparities across the United Kingdom (UK). It sets out the evidence of the impact universities are making across three main themes, outlines the potential to go further, and makes recommendations for how the government can work with universities to maximise their contributions to generating growth and opportunity across the UK. The recommendations set out in this report will build on the strong track record of universities -- where every pound committed to universities results in jobs, innovation, economic growth, investment and effective and successful policies. Of the recommendations set out in this report, it has four main asks of the government: (1) Rapidly expand the University Enterprise Zones (UEZ) programme across England and their equivalents across the UK; (2) Create enterprise and opportunity hubs across the UK; (3) Support universities' involvement in a new range of sector deals; and (4) Embed and engage universities in local, devolved and national initiatives and policymaking.