Evidence is mounting that women in academia have disproportionately been affected by the pandemic. Recent research points to new gender gaps in productivity and publishing, with fewer women publishing articles and manuscripts. And in addition to these professional challenges, women in academia are also facing unique personal challenges during the pandemic, including balancing childcare and home responsibilities while working towards achieving tenure in an academic pipeline where it is already challenging for women to succeed. Likewise, caregivers--those who have care-giving responsibilities for children or a family member, representing roughly one in five Americans--have also been affected substantially by the pandemic. Many have found themselves in new or deepened caregiver roles during the pandemic. In the fall of 2020, the authors fielded the Ithaka S+R COVID-19 faculty survey, a survey designed to help colleges and universities improve their engagement with and support for their faculty members, at a large urban university system of two- and four-year institutions within the US. The findings from this project not only reinforce many of the same trends that others are reporting--that women and caregivers are at a huge disadvantage as the pandemic persists--but bring new data to the fore on the particular activities where these gaps exist. This issue brief serves to outline these disparities in greater detail and highlight where there are opportunities for institutions to implement changes in order to address the growing threat to the success of women and caregivers in academia.