This guide describes the use of a multi-tiered systems of support (MTSS) framework, like positive behavioral interventions and supports (PBIS), to restart classrooms and schools in a manner that all students, families, and educators are supported effectively, efficiently, and relevantly. This guide is not a primer on MTSS or PBIS. (For a basic introduction, visit PBIS.org.6) This guide is a set of considerations for experienced leadership teams to enhance, adjust, or adapt state, district, school, and classroom action plans to (a) meet their needs during the phases of crisis response and recovery and (b) return to a safe and positive learning environment. [This guide was co-authored by the Lead for Literacy Center.]