This report is organized around 10 challenges (and associated solutions) based on data from a survey of 1,609 survey respondents, each of whom was screened to ensure that they had firm plans to enroll in a fully online program in the next year (online course takers in otherwise hybrid or classroom programs were not eligible). They also had to be planning to enroll in a credit-bearing program, ranging from an undergraduate certificate to a professional doctorate. Data are organized in most cases in one of two ways--by credential level (undergraduate degree, graduate degree, or non-degree credential) or age (five-year brackets). Throughout 2022, Ruffalo Noel Levitz (RNL) will release additional reports on each degree level specifically, for non-degree only (with more specificity by each type of non-degree credential), for those from underrepresented backgrounds, and by age (particularly one documenting the preferences of online students under the age of 25 who comprise 24 percent of the sample).