Trends in International Mathematics and Science Study (TIMSS) is an international comparative study designed to measure trends in mathematics and science achievement at grades 4 and 8, as well as to collect information about educational contexts (such as students' schools, teachers, and homes) that may be related to student achievement. TIMSS has been administered every 4 years since 1995, with the seventh and most recent administration, in 2019, providing a 24-year trend line. The United States has participated in every administration of TIMSS, which includes 1995, 1999, 2003, 2007, 2011, 2015, 2019 for the eighth grade and all but 1999 for the fourth grade (when it was not administered internationally). TIMSS is designed to align broadly with mathematics and science curricula in the participating education systems and, therefore, to reflect students' school-based learning. Because it is an international study, TIMSS provides valuable benchmarking information on how U.S. students compare to students around the world. The U.S. TIMSS 2019 Technical Report and User's Guide provides an overview of the design and implementation of TIMSS 2019 in the United States and includes guidance for researchers using the U.S. datasets. Part 2 contains Appendix D: TIMSS 2019 Questionnaires. Part 3 contains Appendix E: TIMSS 2019 Questionnaire Adaptations and Appendix F: U.S. TIMSS 2019 Nonresponse Bias Analysis. [For "U.S. Technical Report and User Guide for the 2019 Trends in International Mathematics and Science Study (TIMSS). Part 1. NCES 2022-049," see ED623028. For "U.S. Technical Report and User Guide for the 2019 Trends in International Mathematics and Science Study (TIMSS) (Continued). Part 2. Appendix D. NCES 2022-049," see ED623029.]