The tenth annual Boston Opportunity Agenda Report Card takes a closer look at the impact of two years of pandemic on the achievement of students on key indicators from kindergarten through college and adult education. It finds mixed results for Boston's public and public charter school students, with some areas seeing much larger changes triggered by the pandemic than others. This report card contains the most up-to-date information available on Boston's education pipeline, including measures on: (1) school readiness; (2) third-grade reading proficiency; (3) sixth-grade mathematics proficiency; (4) dropout rates; (5) high school completion; (6) postsecondary enrollment and completion statistics; and (7) adult postsecondary attainment. [Current partners are identified in the programmatic updates section of the report card. For the Ninth Annual Report Card, see ED613767.]