Recognising growing concerns about the incidence of staff-to-student sexual misconduct in higher education, this guidance aims to change the culture of higher education to one that prevents sexual misconduct from occurring and ensures high standards of behaviour and safety for all members of the university community. The guidance was developed by an advisory group which included representatives from professional and research bodies in the United Kingdom higher education sector and academics and expert policy advisers, and practitioners from across the sector in the field of gender-based violence. The guidance is based on five foundational principles that should inform a university's approach to tackling staff-to-student sexual misconduct: (1) Universities have a legal and ethical responsibility for the safety and wellbeing of all students and staff; (2) Universities are diverse and autonomous, and need to use their own approaches in carrying out this guidance; (3) Addressing staff-to-student sexual misconduct should be part of a broader programme of work designed to tackle all forms of harassment and institutional inequalities. This principle recognises that universities need to establish an organisational culture that supports and promotes equality, diversity and inclusion and which is unequivocal that harassment and abuse will not be tolerated; (4) Tackling staff-to-student sexual misconduct is complicated and challenging. To do so requires change at individual, organisational, community, and societal levels; and (5) Collective responsibility and a whole university response within the university community is needed to tackle this problem. This guidance also builds on an earlier strategic framework, "Changing the Culture: Report of the Universities UK Taskforce Examining Violence against Women, Harassment and Hate Crime Affecting University Students" (ED613329), which focused on tackling harassment occurring between students.