Career and technical education (CTE) programs offer students opportunities to explore potential careers while learning technical and employability skills. Education administers funds for these programs through the Strengthening Career and Technical Education for the 21st Century Act (Perkins V). For fiscal year 2021, Congress authorized about $1.3 billion to support CTE programs through Perkins V, and about 11 million students participated in these programs in 2019-2020. Perkins V and a U.S. House of Representatives Committee report accompanying a fiscal year 2021 appropriations bill include provisions for GAO to examine CTE service and funding strategies. In addition, GAO was separately asked to review programs funded through Perkins V. This report examines: (1) strategies selected recipients of federal CTE funds have used to support their CTE programs and assist different student populations; (2) challenges CTE stakeholders face and how they are addressing them; and (3) how Education supports CTE programs. GAO interviewed officials from Education, state officials in Delaware, Georgia, Ohio, and Washington (selected based on CTE enrollment of students from different populations, among other factors), representatives from eight CTE program providers, and 14 additional CTE stakeholders, including business representatives. GAO also reviewed CTE funding information from the eight CTE program providers; and reviewed relevant federal laws and Education documents.