Politicians, legislators, and educational policy decision-makers are in agreement with education scholars that the enrichment and productivity of creative businesses, technological innovations, medical advancements, and a sustained global competitiveness are contingent on a nation acquiring a robust STEM-ready workforce. The problem addressed in this study was Latinas are underrepresented in STEM careers possibly due to lack of motivators to learn the skills required and a lack of educational programs that may increase Latinas' self-efficacy regarding the pursuit of STEM careers. Educational program initiatives provided to schools with a large population of academically struggling Latinas have not been effective to promote uniform interests leading to a STEM occupation. The purpose of this qualitative single case study involved an exploration of Latinas' perceived barriers and motivators that effectively increased interests in educational programs that could result in improved STEM self-efficacy. Albert Banduras' theory on self-efficacy, which attributed intrinsic motivation, such as "to do well in school" framed this study. Six recruited participants completed a demographical survey and participated in a face-to-face interview followed by member checking. A review of pre-recorded YouTube webinars were used to help triangulate the data from the interviews. Findings revealed a motivator to Latina STEM self-efficacy resulted from exposure to STEM courses while enrolled in school that included hands on activities with people who looked like them. The perceived inhibitors were attributed to strong cultural ties to family traditions, expectations, gender bias, and lack of support to pursue a career. Recommendations for practice include strategically planning courses based on student demographics, building self-efficacy, and promoting awareness of the benefits of acquiring STEM skills to pursue a career. Recommendations for future research include a longitudinal study of Latinas categorized by demographics to better capture their choices. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]