Since 1997, the Head Start Family and Child Experiences Survey (FACES) has been a major source of information on the Head Start program and the preschool children ages 3 to 5 who attend the program. As part of its management of Head Start, the federal government divides Head Start programs into 12 regions. Regions XI and XII are not based on geography; instead, Head Start defines the regions by the populations they serve. Region XI serves children and families in programs operated by federally recognized American Indian and Alaska Native tribes. In 2015, a new study--the American Indian and Alaska Native Head Start Family and Child Experiences Survey (AIAN FACES 2015)--focused on the children and families in Region XI. AIAN FACES 2019 is the second round of this national study in Region XI Head Start. Mathematica and its partner, Educational Testing Service, conducted the study for the Office of Planning, Research, and Evaluation, Administration for Children and Families, U.S. Department of Health and Human Services. The tables in this report describe the children enrolled in Region XI Head Start programs in fall 2019, their family backgrounds and home environments. In addition, the report provides information on the AIAN FACES 2019 study methodology, sample, and analytic methods. The study design is the same as the design for AIAN FACES 2015. The purpose of this report is to: (1) provide information about the AIAN FACES study, including the background, design, methodology, assessments, and analytic methods; and (2) report detailed descriptive statistics (averages, response ranges, and percentages) in a series of tables on children and their families. Specific topics examined include: (1) Children's characteristics, family background, and home environment; (2) Children's cognitive skills; (3) Children's social-emotional skills; and (4) Children's physical health and disability status. [For the Fall 2015-Spring 2016 report, see ED617161.]