As the 2020-2021 school year began, the Wisconsin-Minnesota Comprehensive Center (WMCC)--working with Minnesota Department of Education (MDE) and housed at the University of Minnesota's (UMN) Center for Applied Research & Educational Improvement (CAREI), the University of Wisconsin-Madison's Wisconsin Evaluation Collaborative (WEC), and Education Analytics (EA)-- determined that surveys of educators, students, and families over the course of the school year would be prudent to capture the experiences of these key groups, learn from this unprecedented time, and plan for the future. This survey, the Safe Learning Survey, was developed to get a true picture of how those being most impacted by the MDE's Safe Learning Plan are experiencing it. The survey is being deployed at three intervals, Winter (February), Spring (May-June), and Fall (October) 2021, with statewide reports following the conclusion of each survey window. The second Safe Learning Survey, the subject of this report, was conducted from May 5, 2021 to June 18, 2021. Over 10,500 respondents, including 2,844 educators, 1,685 students, and 6,004 family members completed the survey this spring. Although the survey was sent statewide via school and district leaders, somewhat uneven and concentrated responses, both geographically and by respondent type, were observed. Additionally, the response rate for this second survey was approximately half the size of that for the first survey from the winter of 2021. It is the continued hope of the WMCC that data from the Minnesota Safe Learning Surveys will continue to provide insights as to how educators, students, and families are feeling about school during this unprecedented time in history. [For the first report, "Minnesota Safe Learning Survey: Winter 2021 Survey of Minnesota Educators, Families, and Students," see ED615428. This report was co-produced by the University of Minnesota, College of Education and Human Development.]