Data in this report reflect responses from 296 four-year and two-year colleges and universities that collectively enroll approximately 1,700,000 undergraduate students (according to data reported to IPEDS). Respondents participated in the Ruffalo Noel Levitz (RNL) national electronic poll of Effective Practices for Student Success, Retention, and Completion between March 8 and April 8, 2021. The poll was emailed to student affairs, academic affairs, and retention officers at accredited, degree-granting institutions across the United States. Respondents to the poll included 132 four-year private institutions, 93 four-year public institutions, and 71 two-year institutions. To report the findings as accurately as possible, the rankings of effectiveness were based only on the relative effectiveness options that were given to respondents: "very effective," "somewhat effective," and "minimally effective," and do not include the fourth response, "practice not used." The findings are relayed in the following sections: (1) Most Widely Used Strategies and Tactics for Student Success, Retention, and Completion; (2) Top Programs and Strategies Targeted to Specific Populations to Increase Student Success, Retention, and Completion; (3) Management Practices for Optimizing Student Success, Retention, and Completion; (4) Technology; (5) New Strategies; (6) General Trend of Cohort Graduation Rate; (7) What Guides Retention Planning Efforts?; (8) Student Success, Retention, and Completion Committee; (9) Chief Retention Officer; and (10) Influence of Performance-Based Funding?. [For "2019 Effective Practices for Student Success, Retention, and Completion Report," see ED606629.]