Amid the COVID-19 pandemic, extended school shutdowns, and renewed protests about racial injustice, schools confront sharp increases in student learning, behavioral, and emotional challenges. Despite this, the matter of how best to address these pervasive concerns--many of which result from long-standing structural and systemic barriers that necessitate structural and systemic solutions--remains unresolved. More than ever, schools need to address directly barriers to learning and teaching, and to reengage disconnected students. This brief highlights the need and ways to transform systematically how schools address the overlapping learning, behavioral, and emotional problems that interfere with effective instruction. The aim is to provide a blueprint to enable the state, Local Education Agencies (LEAs), and schools to play a greater role in providing student and learning supports, and to do so in ways that enhance equity of opportunity.