As school buildings plan to fully reopen according to decisions made in collaboration with local public health departments, education agency leaders and safety planning partners are implementing protocols for preventing or mitigating infectious disease transmission. Federal agencies have created a variety of resources and tools to help organizations, including schools and school districts, understand the mitigation strategies they can consider implementing to protect students, staff, faculty, and visitors from the COVID-19 pandemic. This Fact Sheet discusses a variety of considerations for education agencies as they explore the use of masks and PPE in the school setting, including understanding recommended types of PPE based on membership and the role different people within the school community play (e.g., school nurses may require full body coverings, administrators may opt to integrate plastic barriers in main offices, food service personnel may be required to wear face masks and gloves); purchasing issues with access and availability; proper usage and disposal of masks and PPE; and ensuring that the needs of those with access and functional needs are met when developing proper use protocols and trainings.