Individuals have found their lives upended by the effects of the COVID-19 pandemic and are facing unprecedented challenges in all corners of life. In response, communities have banded together to meet the immediate health, economic, and basic day-to-day needs of families. Joining local efforts, afterschool programs continue to be a source of support to the children and families in their community as they adapt to the challenging circumstances and stressors created by the pandemic. This issue brief, complemented by in-depth afterschool program profiles, explores the range of ways in which programs have responded to the needs of their community and placed the well-being and safety of children and families at the forefront of program efforts.