Like many other industries, higher education is in the midst of a disruption. Perhaps, there is no more significant threat during this period of disruption than student enrollment. The author's hypothesis is that industry disruption represents both enrollment opportunities and threats. For this reason, "Managing the Student Enrollment Obsession" is primarily designed to provide a roadmap for colleges and universities to successfully navigate the changes ahead. In the book, environmental scan data and a literature review are leveraged to forecast the potential implications for higher education of emerging trends, particularly as they relate to student enrollment. The environmental scan includes international, national, and regional findings associated with traditional and nontraditional undergraduate and graduate students attending U.S. postsecondary institutions or in the pipeline of potential students. While the literature review focuses on student enrollment, it more broadly examines other practices within the academy, such as teaching, learning, and service delivery. The review also extends beyond higher education to consider related trends in technology, market forces, as well as the attributes and expectations of Generation Z and Millennials. Results of the meta-analysis reveal that the changing composition of students with diverse learning needs and expectations combined with exponential technological advances, increased competition for students, rising college costs and student loan debt have created the perfect storm. How institutions respond in this era of disruption will determine if this is a time of innovation or for some, an extinction event. From the analysis, the author suggests possible implications for colleges and universities viewed through the lenses of academic program innovation, student recruitment, student retention, and enrollment planning. [This work was published by SEM Works.]