Schools, working together with local health departments, have an important role in slowing the spread of diseases and protecting vulnerable students and staff, to help ensure students have safe and healthy learning environments. This guidance will help public and private child care programs, K-12 schools, and their partners understand how to help prevent the transmission of COVID-19 within child care and school communities and facilities. It also aims to help child care programs, schools, and partners react quickly should a case be identified. The guidance includes considerations to help administrators plan for the continuity of teaching and learning if there is community spread of COVID-19. It is organized into three categories based on the level of community transmission: (1) when there is no community transmission (preparedness phase); (2) when there is minimal to moderate community transmission; and (3) when there is substantial community transmission. Guidance is also provided for when a confirmed case has entered a school, regardless of the level of community transmission. All decisions about implementing school-based strategies (e.g., dismissals, event cancellations, other social distancing measures) should be made locally, in collaboration with local health officials who can help determine the level of transmission in the community. This interim guidance is based on what is currently known about the transmission and severity of coronavirus disease 2019 (COVID-19). The US Centers for Disease Control and Prevention (CDC) will update this guidance as needed and as additional information becomes available.