This interim guidance is based on what is currently known about the transmission and severity of coronavirus disease 2019 (COVID-19). The US Centers for Disease Control and Prevention (CDC) will update this guidance as needed and as additional information becomes available. This interim guidance is intended for administrators of public and private institutions of higher education (IHE). Institutions of higher education (IHE), working together with local health departments, have an important role in slowing the spread of diseases, and protecting vulnerable students, staff, and faculty to help ensure a safe and healthy learning environment. Guidance for IHE is organized into three categories based on the level of community transmission: (1) when there is no community transmission (preparedness phase); (2) when there is minimal to moderate community transmission; and (3) when there is substantial community transmission. IHE administrators are advised to consult with their local health department to determine what level of transmission is currently occurring in their community. Guidance is also provided for when a confirmed case has entered an IHE, regardless of community transmission. All decisions about implementing IHE-based strategies (e.g., class suspensions, event cancellations, other social distancing measures) should be made in collaboration with local health officials.