Traditionally defined, Adverse Childhood Experiences, or ACEs, include experiences of child maltreatment and other family problems such as domestic violence and parental incarceration. These ACEs are common, frequently co-occur, and are associated with a whole host of negative social outcomes, health risk behaviors, psychiatric and substance use disorders, and medical health problems. This report reviews the state of the science on programs designed to prevent ACEs and mitigate their negative effects, and surveys the Baltimore City landscape in terms of prevalence of ACEs and the availability of interventions to address ACEs. The recommendations derived from this report are organized into seven sections: (1) prevention; (2) intervention; (3) service systems; (4) community-wide initiatives; (5) structural; (6) policy; and (7) performance evaluation. The legislative recommendations outlined in the closing section of this report to prevent and/or reduce the impact of ACEs, proposed by the Maryland Essentials for Childhood and the State Council on Child Abuse and Neglect should be supported. Several other action-oriented recommendations to advance these efforts are offered.