The mission of the Houston Independent School District's (HISD) Career and Technical Education (CTE) program is to empower students with the academic and technical skills needed to strengthen the economic and social foundation of the city of Houston and beyond. HISD CTE programs are also tailored to prepare students to meet the current and future needs of Houston's industries, and preparing students for success in their field of interest following graduation. The purpose of this 2015-2016 report is to provide an overview of the initiatives of the CTE program, academic outcomes on the State of Texas Assessments of Academic Readiness (STAAR) End-Of-Course (EOC) exams, and matriculation rates of CTE students in HISD. Key findings include: (1) There was a 12.2 percent increase in CTE enrollment overall from the 2014-2015 school year to the 2015-2016 school year. The number of CTE 2 and 3 students, who were enrolled in a coherent sequence, was 22,123 in 2015-2016, a 5.8 percent increase from the 2014-2015 school year. There was a 22.2 percent increase in the number of CTE 1 students who were enrolled in CTE classes as electives, from 13,232 in 2014-2015 to 16,168 in 2015-2016; (2) Higher percentages of CTE students met the Level II: Satisfactory Student Standard on the 2016 Algebra I, English II, and U.S. History EOC exams; and (3) The percentage of CTE students from the ninth-grade cohort graduating from high school in a four-year period decreased from 91.5 percent in 2014 to 90.5 percent in 2015. These rates continue to exceed the graduation rates of the district as a whole. Recommendations for improvement are included.