Section 29.182 of the Texas Education Code (TEC) makes provision for all students in the State of Texas to participate in Career and Technical Education (CTE) programs. CTE programs incorporate competencies that lead to the attainment of academic and technical skills, industry recognized certificates, licenses, and credentials for employment as well as provide opportunities for students to earn college credit for completed coursework (State of Texas, 2013). The Houston Independent School District (HISD) offers non-coherent and coherent-sequence of CTE courses with rigorous content in 16 high school programs. The purpose of this evaluation was to determine trends in CTE course enrollment in HISD, and to analyze students' performance relative to their peers who did not participate in the program using the State of Texas Assessments of Academic Readiness (STAAR) End-of-Course (EOC) examination results. The study was guided by four questions and used descriptive statistics and trend data to answer these questions. Finally, multiple regression analyses were used to predict students' performance on the STAAR Algebra I, Biology, English I, English II, and U.S. History EOC exams using selected demographic and educational predictors. Among the key findings were: (1) While the number of students who were enrolled in a non-coherent sequence of CTE courses declined by 6.2 percent, the number of students enrolled in a coherent sequence of courses increased by 10.8 percent between the 2016-2017 and the 2017-2018 academic years; (2) Overall, 91.5 percent of the 6,170 CTE students who took an industry certification exam received an industry certification during the 2017-2018 school year; (3) There was a 19.5 percent increase in the number of CTE graduates compared to a 4.2 percent increase for the district between the Class of 2016 and the Class of 2017; and (4) The 2017 annual grades 9-12 school dropout rate for CTE students was 2.7 percent compared to 4.6 percent for HISD.