During the 2014-2015 academic year, 1,148 students registered and 820 elementary, middle, and high-school students played the New Digital Energy Game (NDE) game in the Houston Independent School District (HISD). The NDE game was designed to enrich students' science experiences in order to stimulate their interests and attitudes to pursue science careers. The game was funded by Chevron Corporation and developed by Tietronix, Inc. Paired t-test analysis of a student sample yielded a statistically significant increase in students' overall interest rating in science from pre- to post survey, and a decrease in their overall attitude rating over the same time period. Propensity score, nearest neighbor matching yielded a higher percent of items correct on the mid-year District Level Assessment (DLA) in science for NDE students compared to students who did not participate in the program. The difference between the groups was statistically significant, suggesting that the NDE program had a positive effect on students' DLA science performance. Notable highly statistically significant intercorrelations were as students' post-interest and post-attitude ratings increased, their science DLA results increased.