The purpose of this qualitative, bounded case study was to understand how the specific medium of iTunes U facilitated a high school global collaboration experience for participating teachers and students in Philadelphia, PA, USA and Amsterdam, Netherlands and the academic, social, and emotional benefits participating in such a unique experience offered to students and teachers. In the global collaboration course used for this study, students collaboratively created and published content. For this study, the term "benefits" was defined as "positive effects on academic, social, and emotional growth" that developed as the study progressed. To achieve this purpose, the bounded case study followed the story of the previously described global collaboration course taught using iTunes U to the two high school literature classes, one in Philadelphia, PA, USA and one in Amsterdam, Netherlands. The bounded case study included interviews and focus groups from selected students taking the course, from an administrator from the school in Philadelphia, from the teacher of the Dutch class, and from an iTunes U expert. The following research questions guided this study in order to understand how iTunes U facilitated a global collaboration course and the benefits such a course offered to students. 1. How does using an original iTunes U course facilitate global collaboration? 2. How does the experience of participating in an original iTunes U course with students from another country facilitate social, emotional, and academic growth of students? 3. How does the experience of participating in an original iTunes U course with students from another country prepare students with a skill-set that will help them beyond high school? [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]