Over the past decade, the National Advisory Committee on Rural Health and Human Services (hereinafter referred to as "the Committee") has examined a number of rural issues that touch upon the social determinants of health. The Committee's past work has focused on understanding how conditions and outcomes such as homelessness, childhood poverty, intimate partner violence, opioid misuse and suicide can be mitigated or more effectively addressed through health and human service programs under the purview of the U.S. Department of Health and Human Services (HHS). In this policy brief, the Committee takes up adverse childhood experiences or ACEs, another layer and set of conditions that may exacerbate rural health disparities and outcomes. ACEs refer to any form of chronic stress or trauma (e.g., abuse, neglect, and household dysfunction) that, when experienced during childhood and adolescence, can have both short- and long-term impacts on an individual's development, health and overall well-being. The brief emphasizes the importance of prevention, education, and awareness at the local, state, and federal levels of health and human service delivery. Additionally, it provides a set of actionable recommendations that advise the Secretary and HHS on how to better address ACEs and their outcomes in an effort to develop comprehensive, integrated, federal partnerships. [This report was completed by the National Advisory Committee on Rural Health and Human Services.]