By combining the benefits from Intelligent Tutoring Systems (ITSs) and video games, educational games offer the unique potential to capture learners' interest, compel them to persist with targeted tasks, and can result in improved mastery of educational content and skills. These benefits are described within the context of educational game research and incorporated into two new potential frameworks. The potential frameworks are designed to help structure findings from various literature bases in a manner that helps to inform future system designs and illustrates possible contributions to and the importance of considering timescales for evaluating effects of educational games. Tentative empirical support for these frameworks is provided through empirical results with iSTART-ME, along with general conclusions from the research presented. [This chapter was published in: Y. Baek (Ed.), "Game-Based Learning: Theory, Strategies and Performance Outcomes," (pp.97-121). Hauppauge, NY:? Nova Science Publishers, Inc., 2017. (ISBN-978-1-5361-1900-8)]